Line A (Orange): Battistini to Anagnina. Key tourist stops are Ottaviano-San Pietro for Vatican Museums (use Ottaviano exit for shortest walk), Spagna for Spanish Steps and luxury shopping, Barberini-Fontana di Trevi (take Bernini exit), Repubblica-Teatro dell'Opera for Diocletian Baths, and Termini for central station connections.

Line B (Blue): Runs Laurentina to Rebibbia but splits at Bologna station. Take Rebibbia direction for city center. Essential stops include Colosseo (use Colosseum exit for amphitheater, Oppian Hill exit for Roman Forum back entrance), Cavour for easy Forum access via Via dei Fori Imperiali, Piramide for Testaccio market and Trenitalia trains to Ostia beaches, and EUR Magliana for modern business district.

Line C (Green): Monte Compatri-Pantano to San Giovanni. Newest line connecting eastern suburbs. Transfer to Line A at San Giovanni for Vatican access. Most tourists won't need this line unless staying in Centocelle area.

Operating Hours: Monday-Thursday 5:30am-11:30pm, Friday-Saturday 5:30am-1:30am, Sunday 5:30am-11:30pm. After closure, night buses MA, MB, MC follow metro routes. Single ticket €1.50 valid 100 minutes includes all metro, bus, tram transfers.